The Early Inflammatory Response to Virulent and Avirulent Influenza Viruses

Grant number: 400226

Abstract

Innate immune mechanisms are vital components of host defences against pathogens. In this proposal I aim to investigate the particular mechanisms that operate in early defence against influenza virus infection and compare the ability of virulent and avirulent virus strains to (i) be recognized by components of the innate immune system, and (ii) to trigger an early inflammatory response to infection. It is anticipated that virulent virus strains have adapted to avoid recognition by innate cells such as macrophages. By avoiding this route of uptake and destruction, the virus is free to infect and replicate in other cells of the respiratory tract. Furthermore, by evading macrophage entry, the v..

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Related publications (4)

Influenza viruses differ in ability to infect macrophages and to induce a local inflammatory response following intraperitoneal injection of mice

PC Reading, PG Whitney, DL Pickett, MD Tate, AG Brooks

2010-08-01

Strains of influenza A virus show marked differences in their ability to infect murine macrophages (Mφ) such that strain A/PR/8/34..

Neutrophils ameliorate lung injury and the development of severe disease during influenza infection

MD Tate, YM Deng, JE Jones, GP Anderson, AG Brooks, PC Reading

2009-12-01

The clinical response to influenza infection ranges from mild disease to severe pneumonia and it remains unclear whether the infla..

Loss of a single N-linked glycan from the hemagglutinin of influenza virus is associated with resistance to collectins and increased virulence in mice

PC Reading, DL Pickett, MD Tate, PG Whitney, ER Job, AG Brooks

2009-11-23

Background: Glycosylation on the globular head of the hemagglutinin (HA) protein of influenza virus acts as an important target fo..

The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of mice

MD Tate, AG Brooks, PC Reading

2008-08-01

Background: Neutrophils have been shown to play a role in host defence against highly virulent and mouse-adapted strains of influe..

University of Melbourne Researchers

Patrick Reading